Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants
What Medicare pays for 81291, what providers bill, and how the price varies across 14 states, drawn from CMS 2023 claims data.
81291 · the short answer
For gene analysis (5, 10-methylenetetrahydrofolate reductase) common variants, Medicare pays about $63.93 while providers bill $125.71 on average, a 2.0× markup, one of the smaller markups in the catalog. State-level Medicare rates range 2% from lowest to highest.
- Medicare pays
- $63.93
- Providers bill
- $125.71
- Markup
- 2.0×
- Markup percentile
- 3th
Medicare amounts are CMS-published; markup = average submitted charge ÷ average Medicare payment.
Price Range Across States
What You Might Pay
Estimated using RAND 2024 commercial-to-Medicare ratios. Actual prices vary by insurer, plan, and facility.
How we estimate these prices
These estimates are based on the RAND Hospital Price Transparency Study (4th Edition, 2024), which found that commercial insurance prices average 224% of Medicare rates nationally. We apply category-specific ratios: Genetic/Molecular Test procedures average 2.24x Medicare rates. Cash/self-pay estimates blend typical cash discounts (55% of billed charges) with Medicare-based estimates (150% of allowed amounts). These are statistical estimates, not quotes. Contact your insurer or provider for actual costs.
Where this markup sits nationally
Markup (billed ÷ Medicare) across 8,901 procedures with a meaningful Medicare rate
2 more affordable than 3% of 8,901 procedures
Each bar is a band; taller bars hold more procedures. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.
Source CMS Medicare Physician & Other Practitioners · 2023
Prices by State
| State | Medicare Payment | Billed Charge |
|---|---|---|
| Arizona | $64.03 | $200.81 |
| Arkansas | $64.03 | $130.68 |
| Colorado | $64.03 | $348.83 |
| Maryland | $64.03 | $332.87 |
| Mississippi | $64.03 | $97.12 |
| New Mexico | $64.03 | $275.00 |
| Ohio | $64.03 | $466.06 |
| Oklahoma | $64.03 | $144.07 |
| Texas | $64.02 | $99.86 |
| Florida | $64.01 | $114.55 |
| Pennsylvania | $63.88 | $139.31 |
| Virginia | $63.58 | $97.53 |
| New Jersey | $63.56 | $189.90 |
| Louisiana | $62.64 | $103.01 |
What the Data Says About Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants
Across 14 states with reporting providers, CPT code 81291 (Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants) shows a national average Medicare payment of $63.93 against an average billed charge of $125.71. That gap, a 2.0x markup, or 97% above the Medicare allowed amount, is among the tightest billed-to-paid spreads we track, this code's chargemaster rate tracks unusually close to the Medicare benchmark.
Genetic/Molecular Test procedures like this one saw 17.9K services billed to Medicare in 2023 by 154 distinct providers, serving 17.9K unique beneficiaries. State-level variation is significant: Louisiana reports the lowest average payment at $62.64, while Arizona reports the highest at $64.03. At just 2%, this procedure prices remarkably consistently nationwide, GPCI adjustments barely move the needle for this particular code.
Applying RAND 2024 commercial-to-Medicare ratios specific to the Genetic/Molecular Test category (2.24x), the estimated commercial insurance price lands near $143.20, with self-pay cash discounts commonly bringing the figure closer to $82.52. Within Genetic/Molecular Test, Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants ranks #239 of 298 tracked procedures by national average Medicare payment.
What to do with this
If you may have gene analysis (5, 10-methylenetetrahydrofolate reductase) common variants done, these steps turn the numbers above into a real-world cost estimate.
- Request a Good Faith Estimate from your provider at least 3 business days before a scheduled procedure, under the No Surprises Act it is an enforceable written price.
- Compare gene analysis (5, 10-methylenetetrahydrofolate reductase) common variants costs in your state, Medicare rates vary by locality. Browse states
- Check a hospital’s published cash price, which is often far below the billed charge. Price transparency
- Understand why billed charges run several times the Medicare rate before you negotiate. Read the guide
Figures here are averages and estimates, not a quote. Confirm coverage and out-of-pocket costs with your insurer and provider.
Frequently Asked Questions
How much does Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants cost?
Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants (CPT 81291) is priced fairly consistently nationwide: Medicare pays $63.93 on average, and the $62.64-$64.03 state range stays relatively tight. Providers typically bill $125.71.
Why do providers charge more than Medicare pays?
Providers set their own chargemaster rates (billed charges), which are typically much higher than what any insurer pays. Medicare pays a fixed rate based on the procedure code and geographic location. The billed charge is relevant mainly for uninsured patients, who may face prices closer to the submitted charge.
How much does Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants cost with insurance?
With commercial insurance, gene analysis (5, 10-methylenetetrahydrofolate reductase) common variants costs an estimated $143.20 on average (range: $100.24-$200.48), a moderate premium over Medicare's $63.93. Without insurance, the estimated cash price is $82.52.
Which state has the lowest cost for Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants?
Louisiana and Arizona bookend the range for Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants, at $62.64 and $64.03 respectively - a relatively tight $1.39 spread nationwide.
How many providers perform Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants?
Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants is comparatively uncommon: only 154 providers nationally billed Medicare for it in 2023, serving 17.9K beneficiaries via 17.9K total services.
What is the billed-to-Medicare markup for Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants?
Providers bill 2.0x what Medicare pays for Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants - one of the smaller markups in the catalog at 97% above the Medicare rate.
Related Guides
Tips to reduce out-of-pocket costs
Your right to upfront pricing
How Medicare payments work
Decode charges and codes
Why bills exceed actual costs
Geographic pricing factors
Data from CMS Medicare Physician & Other Practitioners (2023).
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainProcedure is rendered directly from CMS Medicare Physician & Other Practitioners data, no number is typed in by an editor. This page draws directly on CMS Medicare Physician & Other Practitioners data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.