CMS 2023 data Official source Free · public domain

Genetic/Molecular Test

298 procedures in Genetic/Molecular Test. Medicare reimbursement averages $795.12 per service; billed charges average N/A. Source: CMS Medicare Physician & Other Practitioners 2023.

View my watchlist RSS updates for this category

Where this category sits

Among CMS procedure categories, Genetic/Molecular Test ranks #5 of 73 by average Medicare payment ($795.12 per service across its 298 procedure codes).

#5
of 73 categories by avg payment
$795.12
avg Medicare payment
298
procedure codes

Category placement is ordered by average Medicare payment per service, descending, among all published procedure categories.

DNA, RNA, and genetic testing including proprietary lab tests

298 procedures · Avg Medicare payment: $795.12

Code Procedure Medicare Billed
88185 Flow Cytometry Technique For Dna Or Cell Analysis, Each Additional Marker $19.85 $103.86
87150 Identification Of Organisms By Genetic Analysis, Amplified Probe Technique $34.32 $62.63
87635 Amplifed Dna Or Rna Probe Detection Of Severe Acute Respiratory Syndrome Coronavirus 2 (covid-19) Antigen $50.08 $136.02
88360 Microscopic Genetic Analysis Of Tumor, Manual $47.93 $204.91
81528 Gene Analysis (colorectal Cancer) $498.52 $680.52
86225 Measurement Of Dna Antibody, Native Or Double Stranded $13.42 $93.08
88189 Flow Cytometry Technique For Dna Or Cell Analysis, 16 Or More Markers $66.15 $395.89
88374 Microscopic Genetic Analysis Of Tissue, Computer-Assisted Technology, Initial Procedure, Each Multiplex Procedure $92.99 $330.50
88361 Microscopic Genetic Analysis Of Tumor, Using Computer-Assisted Technology $51.28 $291.78
88377 Microscopic Genetic Analysis Of Tissue, Manual, Each Additional Multiplex Stain Procedure $138.78 $577.52
87563 Detection Of Mycoplasma Genitalium By Dna Or Rna Probe $34.35 $66.02
88184 Flow Cytometry Technique For Dna Or Cell Analysis, First Marker $61.38 $233.31
88271 Dna Testing For Genetic Defects $20.98 $114.49
88365 Genetic Sequencing Localization, Initial Procedure $61.02 $228.83
88291 Interpretation And Report Of Genetic Testing $26.35 $115.28
88364 Genetic Sequencing Localization, Each Additional Procedure $46.76 $171.92
88363 Examination Of Archival Tissue For Genetic Analysis $15.72 $94.40
81279 Gene Analysis (janus Kinase 2) Targeted Sequence Analysis $180.61 $272.74
88188 Flow Cytometry Technique For Dna Or Cell Analysis, 9 To 15 Markers $48.39 $373.67
88275 Chromosome Analysis For Genetic Defects, Analyze 100-300 Cells $50.02 $208.40
81307 Gene Analysis (partner And Localizer Of Brca2) Full Sequence Analysis $661.45 $803.23
81339 Gene Analysis (mpl Proto-Oncogene, Thrombopoietin Receptor) Sequence Analysis Of Exon 10 $181.32 $225.41
81223 Gene Analysis (cystic Fibrosis Transmembrane Conductance Regular) Full Gene Sequence $474.68 $576.78
81209 Gene Analysis (bloom Syndrome, Recq Helicase-Like) $38.51 $43.92
81249 Gene Analysis (glucose-6-Phosphate Dehydrogenase) Full Sequence Analysis $587.66 $661.47
81238 Gene Analysis (coagulation Factor Ix) Full Sequence Analysis $587.04 $696.84
81242 Gene Analysis (fanconi Anemia, Complementation Group C) Common Variant $35.89 $43.23
81256 Gene Analysis (hemochromatosis) Common Variants $64.02 $264.11
81250 Gene Analysis (glucose-6-Phosphatase, Catalytic Subunit) Common Variants $57.32 $70.88
81321 Gene Analysis (phosphatase And Tensin Homolog), Full Sequence Analysis $582.79 $693.11
81519 Test For Detecting Genes Associated With Breast Cancer $3,779.15 $4,618.89
88356 Microscopic Genetic Analysis Of Nerve Tissue $165.22 $482.07
88187 Flow Cytometry Technique For Dna Or Cell Analysis, 2 To 8 Markers $27.09 $268.56
81298 Gene Analysis (muts Homolog 6 [e Coli]) Full Sequence Analysis $628.67 $745.79
81317 Gene Analysis (postmeiotic Segregation Increased 2 [s Cerevisiae]) Full Sequence Analysis $662.78 $784.93
81241 Gene Analysis (coagulation Factor V) Leiden Variant $71.85 $132.88
0242U Gene Analysis Of 55-74 Genes Associated With Solid Organ Cancer In Cell-Free Circulating Dna, Targeted Genomic Sequence Analysis Panel $4,890.35 $8,550.00
81490 Test For Detecting Genes Associated With Rheumatoid Arthritis Using Immunoassay Technique $823.73 $985.60
88264 Chromosome Analysis For Genetic Defects, Analyze 20-25 Cells $141.32 $433.02
81542 Mrna Gene Expression Analysis Of 22 Genes In Prostate Tumor Tissue $3,788.63 $5,150.68
0345U Genomic Analysis Panel Of 15 Genes For Detection Of Abnormalities Assocated With Mental Health Disorders $1,323.59 $5,504.48
81291 Gene Analysis (5, 10-Methylenetetrahydrofolate Reductase) Common Variants $63.93 $125.71
86226 Measurement Of Dna Antibody, Single Stranded $11.77 $50.17
88368 Microscopic Genetic Analysis Of Tissue, Manual, Initial Procedure $60.44 $358.48
81226 Gene Analysis (cytochrome P450, Family 2, Subfamily D, Polypeptide 6) Common Variants $440.26 $852.92
0326U Targeted Genomic Sequence Analysis Of 83 Or More Genes In Cell Free Circulating Dna For Detection Of Abnormalities Associated With Solid Organ Cancers $3,533.29 $9,650.00
81334 Gene Analysis (runt Related Transcription Factor 1) Targeted Sequence Analysis $322.56 $362.50
81345 Gene Analysis (telomerase Reverse Transcriptase) Targeted Sequence Analysis $181.49 $204.50
81270 Gene Analysis (janus Kinase 2) Variant $89.69 $398.44
81309 Gene Analysis (partner And Localizer Of Brca2) Targeted Sequence Analysis $269.32 $300.30
0037U Dna Gene Analysis Of 324 Genes In Solid Organ Tumor Tissue $3,421.48 $5,800.00
81311 Gene Analysis For Cancer (neuroblastoma) $289.83 $333.65
81305 Gene Analysis (myeloid Differentiation Primary Response 88) For P.leu265pro Variant $171.83 $228.51
81189 Gene Analysis (cystatin B) Of Full Sequence $268.69 $334.13
81320 Gene Analysis (phospholipase C Gamma 2) For Common Variants $285.51 $312.38
88369 Microscopic Genetic Analysis Of Tissue, Manual, Each Additional Procedure $53.64 $267.95
81185 Gene Analysis (calcium Voltage-Gated Channel Subunit Alpha1 A) Of Full Sequence $822.71 $896.06
81302 Gene Analysis (methyl Cpg Binding Protein 2) Full Sequence Analysis $517.16 $552.86
0340U Dna Assays For Detection Of Minimal Residual Disease In Cancer $3,837.98 $4,996.64
0312U Analysis Of 8 Igg Autoantibodies And 2 Cell-Bound Complement Activation Products Associated With Autoimmune Disease, Using Enzyme-Linked Immunosorbent Immunoassay (elisa), Flow Cytometry And Indirect Immunofluorescence In Serum Specimen Or Plasma And Whole $823.06 $1,085.61
81191 Gene Analysis (neurotrophic Receptor Tyrosine Kinase 1) Translocation Analysis $203.14 $224.69
81260 Gene Analysis (inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Complex-Associated Protein) Common Variants $38.52 $43.41
0005U Test For Detecting Genes Associated With Prostate Cancer In Urine $744.28 $995.00
81192 Gene Analysis (neurotrophic Receptor Tyrosine Kinase 2) Translocation Analysis $203.15 $226.02
0112U Gene Analysis For Detection Of Infectious Agent And Drug Resistance Gene $348.14 $504.33
81312 Gene Analysis (poly[a] Binding Protein Nuclear 1) For Abnormal Alleles $134.26 $152.23
81286 Gene Analysis (frataxin) Of Full Sequence $269.24 $299.76
81243 Gene Analysis (fragile X Mental Retardation) Abnormal Alleles $55.85 $67.45
81171 Gene Analysis (fragile X Mental Retardation 2) For Abnormal Alleles $134.13 $150.16
81251 Gene Analysis (glucosidase, Beta, Acid) Common Variants $46.30 $55.03
81325 Gene Analysis (peripheral Myelin Protein 22), Full Sequence Analysis $753.97 $841.92
81225 Gene Analysis (cytochrome P450, Family 2, Subfamily C, Polypeptide 19) Common Variants $285.11 $483.02
81200 Gene Analysis (aspartoacylase) $46.30 $53.76
81255 Gene Analysis (hexosaminidase A) Common Variants $50.42 $58.61
81351 Gene Analysis (tumor Protein 53) Full Sequence Analysis $628.71 $729.35
81219 Gene Analysis (calreticulin), Common Variants $118.99 $415.81
0089U Gene Expression Profiling Of Melanoma In Superficial Sample Collected By Adhesive Patch $743.94 $1,299.66
81529 Mrna Gene Analysis Of 31 Genes In Skin Melanoma Tissue Specimen $7,049.14 $8,500.00
81329 Gene Analysis (survival Of Motor Neuron 1, Telomeric) For Dosage/deletion $134.14 $148.60
81546 Mrna Gene Analysis Of 10,196 Genes In Fine Needle Aspiration Thyroid Specimen, Reported As Category Result (e.g. Benign, Suspicious) $3,508.51 $6,400.00
81518 Mrna Gene Analysis Of 11 Genes In Breast Tumor Tissue $3,784.78 $5,398.50
81271 Gene Analysis (huntingtin) For Abnormal Alleles $134.24 $157.15
81541 Gene Analysis Of Prostate Tumor Tissue, Profiling By Real-Time Rt-Pcr Of 46 Genes $3,776.86 $3,900.00
81240 Gene Analysis (prothrombin, Coagulation Factor Ii) A Variant $64.31 $189.95
81595 Test For Detecting Genes Associated With Heart Diseases $3,160.83 $4,300.00
0077U Detection Of Immunoglobulin Paraprotein (m-Protein) In Blood Or Urine $42.26 $177.33
81514 Measurement Of Dna Of Bacteria In Vaginal Fluid Specimen $253.31 $443.11
0239U Gene Analysis Of 311 Or More Genes Associated With Solid Organ Cancer In Cell-Free Dna, Targeted Sequence Panel $3,424.32 $5,800.00
81201 Gene Analysis (adenomatous Polyposis Coli), Full Gene Sequence $764.07 $898.56
81162 Gene Analysis (breast Cancer 1 And 2) Of Full Sequence And Analysis For Duplication Or Deletion Variants $1,783.43 $2,690.77
81218 Gene Analysis (ccaat/enhancer Binding Protein [c/ebp], Alpha) Full Gene Sequence $237.06 $256.26
81295 Gene Analysis (muts Homolog 2, Colon Cancer, Nonpolyposis Type 1) Full Sequence Analysis $373.75 $481.75
0346U Evaluation Of Beta Amyloid Ab40 And Ab42 Ratio $59.35 $649.23
81181 Gene Analysis (ataxin 7) For Abnormal Alleles $134.26 $162.11
81179 Gene Analysis (ataxin 2) For Abnormal Alleles $134.26 $159.85
81419 Gene Analysis Panel For Evaluation Of Genes Associated With Epilepsy $2,399.59 $3,241.25
81344 Gene Analysis (tata Box Binding Protein) For Abnormal Alleles $134.22 $156.76
81343 Gene Analysis (protein Phosphatase 2 Regulatory Subunit Bbeta) For Abnormal Alleles $134.26 $158.72
81180 Gene Analysis (ataxin 3) For Abnormal Alleles $134.26 $159.67
81178 Gene Analysis (ataxin 1) For Abnormal Alleles $134.26 $159.54
88373 Microscopic Genetic Analysis Of Tissue, Computer-Assisted Technology, Each Additional Procedure $44.49 $440.08
81338 Gene Analysis (mpl Proto-Oncogene, Thrombopoietin Receptor) For Detection Of Common Variants $141.91 $492.25
81183 Gene Analysis (ataxin 10) For Abnormal Alleles $134.24 $157.69
81182 Gene Analysis (ataxin 8 Opposite Strand [non-Protein Coding]) For Abnormal Alleles $134.23 $158.84
0117U Analysis Of 11 Biochemical Substances In Urine To Evaluate Likelihood Of Atypical Biochemical Function Associated With Pain $823.55 $840.87
81333 Gene Analysis (transforming Growth Factor Beta-Induced) For Common Variants $134.26 $149.62
81328 Gene Analysis (solute Carrier Organic Anion Transporter Family, Member 1b1) For Common Variant $171.27 $204.60
0360U Onc Lung Elisa 7 Autoant Alg $635.76 $1,054.16
81273 Gene Analysis (v-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog), D816 Variants $122.36 $197.71
81275 Gene Analysis (v-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene) Variants In Codons 12 And 13 $189.17 $253.34
87149 Identification Of Organisms By Genetic Analysis, Direct Probe Technique $19.63 $119.08
0315U Mrna Gene Expression Profiling By Real-Time Polymerase Chain Reaction (rt-Pcr) Of 40 Genes (34 Content And 6 Housekeeping) Associated With Squamous Cell Carcinoma Of Skin In Formalin-Fixed Paraffin-Embedded (ffpe) Tissue Specimen, Algorithm Reported As Ben $6,380.07 $8,500.00
81263 Gene Rearrangement Analysis (immunoglobulin Heavy Chain Locus), Variable Region Somatic Mutation Analysis $288.12 $737.94
81272 Gene Analysis (v-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog), Targeted Sequence $322.54 $415.26
81551 Gene Analysis Of Prostate Tumor Tissue, Profiling By Real-Time Pcr Of 3 Genes $1,982.52 $3,300.00
88280 Chromosome Analysis For Genetic Defects, Additional Karyotypes, Each Study $32.71 $100.26
81300 Gene Analysis (muts Homolog 6 [e Coli]) Duplication Or Deletion Variants $232.91 $296.68
81319 Gene Analysis (postmeiotic Segregation Increased 2 [s Cerevisiae]) Duplication Or Deletion Variants $199.36 $263.68
88367 Microscopic Genetic Analysis Of Tissue, Computer-Assisted Technology, Initial Procedure $58.04 $335.92
81227 Gene Analysis (cytochrome P450, Family 2, Subfamily C, Polypeptide 9) Common Variants $171.23 $214.84
0080U Analysis Of Galectin-3-Binding Protein And Scavenger Receptor Cysteine-Rich Type 1 Protein M130 In Plasma, With Clinical Risk Factors, To Evaluate Probability Of Lung Cancer $3,441.99 $4,275.04
88262 Chromosome Analysis For Genetic Defects, Count 15-20 Cells $122.71 $489.52
81292 Gene Analysis (mutl Homolog 1, Colon Cancer, Nonpolyposis Type 2) Full Sequence Analysis $661.15 $869.75
0047U Mrna Gene Analysis Of 17 Genes In Prostate Tumor Tissue $3,789.07 $4,520.00
81332 Gene Analysis (serpin Peptidase Inhibitor, Clade A, Alpha-1 Antiproteinase, Antitrypsin, Member 1) Common Variants $42.72 $206.31
81233 Gene Analysis (bruton's Tyrosine Kinase) For Common Variants $171.84 $201.86
81177 Gene Analysis (atropin 1) For Abnormal Alleles $134.24 $177.97
88366 Genetic Sequencing Localization, Each Multiplex Procedure $84.02 $433.31
0041U Igm Antibody Detection Test For Borrelia Burgdorferi $16.87 $225.00
86305 Analysis Of Female Reproductive Genetic Marker $20.38 $256.84
0042U Igg Antibody Detection Test For Borrelia Burgdorferi $16.87 $224.91
81274 Gene Analysis (huntingtin) For Characterization Of Alleles $269.33 $276.07
0118U Measurement Of Transplant Donor Cell-Free Dna In Transplant Recipient Plasma $2,681.15 $3,239.90
81297 Gene Analysis (muts Homolog 2, Colon Cancer, Nonpolyposis Type 1) Duplication Or Deletion Variants $208.95 $530.58
81521 Gene Analysis Of Breast Tumor Tissue, Profiling Of 70 Content Genes And 465 Housekeeping Genes $3,782.63 $4,195.51
81323 Gene Analysis (phosphatase And Tensin Homolog), Duplication Or Deletion Variant $293.94 $388.20
81336 Gene Analysis (survival Of Motor Neuron 1, Telomeric) Of Full Sequence $295.27 $622.11
0339U Mrna Expression Profiling Of Genes Associated With High-Grade Prostate Cancer $743.70 $894.68
0108U Computer-Assisted Digital Imaging Of Esophagus Specimen Slides To Evaluate Risk Of Cancer $4,851.00 $5,500.00
0359U Onc Prst8 Ca Alys All Psa $617.56 $797.50
81443 Genomic Sequence Analysis Panel For Severe Inherited Conditions With Sequencing Of 15 Or More Genes $2,389.46 $3,289.44
83951 Oncoprotein (cancer Related Gene) Measurement $63.00 $348.68
81235 Gene Analysis (epidermal Growth Factor Receptor), Common Variants $312.58 $766.93
0044U Igm Antibody Detection Test For Tick-Borne Relapsing Fever Borrelia Group (igg) $14.56 $224.90
81194 Gene Analysis (neurotrophic Receptor Tyrosine Kinase 1, 2, And 3) Translocation Analysis $507.45 $963.72
81294 Gene Analysis (mutl Homolog 1, Colon Cancer, Nonpolyposis Type 2) Duplication Or Deletion Variants $198.28 $275.83
0043U Igm Antibody Detection Test For Tick-Borne Relapsing Fever Borrelia Group (igm) $14.56 $225.00
81440 Test For Detecting Genes $3,251.62 $4,667.68
81448 Gene Analysis Panel For Hereditary Disorders Of The Peripheral Nervous System $568.15 $1,095.06
81432 Test For Detecting Genes Associated With Inherited Breast Cancer-Related Disorders $664.95 $5,644.34
81445 Targeted Genomic Sequence Analysis Panel Of Dna Or Combined Dna And Rna Of 5-50 Genes Associated With Solid Organ Neoplasm $583.15 $2,423.75
81222 Gene Analysis (cystic Fibrosis Transmembrane Conductance Regular) Duplication Or Deletion Variants $425.83 $466.79
0245U Gene Analysis Of 10 Genes And 37 Rna Fusions And Expression Of 4 Mrna Markers, Next-Generation Sequencing, In Fine Needle Aspirate Of Thyroid To Evaluate Risk Of Thyroid Cancer $1,237.60 $3,031.08
0334U Targeted Genomic Sequence Analysis Of 84 Or More Genes For Detection Of Abnormalities Associated With Cancer Of Body Organ $2,857.87 $9,650.00
81342 Gene Rearrangement Analysis Detection Abnormal Clonal Population (t Cell Antigen Receptor Gamma) $197.36 $446.03
86352 Analysis Of Cell Function And Analysis For Genetic Marker $129.57 $314.51
81433 Gene Analysis (breast And Related Cancers), Duplication Or Deletion Variants $430.84 $1,466.96
81288 Test For Detecting Genes Associated With Colon Cancer, Promoter Methylation Analysis $188.43 $467.04
0018U Microrna Gene Analysis Of Thyroid Nodule Tissue $2,926.52 $4,199.65
81330 Gene Analysis (sphingomyelin Phosphodiesterase 1, Acid Lysosomal) Common Variants $46.04 $80.71
88182 Flow Cytometry Technique For Dna Or Cell Analysis $35.61 $100.64
81340 Gene Analysis (t Cell Antigen Receptor Beta) Amplification Methodology $204.34 $550.89
81203 Gene Analysis (adenomatous Polyposis Coli), Duplication Or Deletion Variants $195.99 $257.03
81327 Gene Analysis (septin9) For Promoter Methylation $188.06 $195.08
81290 Gene Analysis (mucolipin 1) Common Variants $38.50 $43.41
81471 Test For Detecting Genes Associated With Intellectual Disability, Duplication/deletion Gene Analysis, At Least 60 Genes $895.72 $955.46
0295U Protein Expression Profiling By Immunohistochemistry Of 7 Proteins (cox2, Foxa1, Her2, Ki-67, P16, Pr, Siah2), With 4 Clinicopathologic Factors (size, Age, Margin Status, Palpability), In Breast Ductal Carcinoma In Situ Tumor Tissue, Algorithm Reported As $4,657.11 $5,991.94
81205 Gene Analysis (branched-Chain Keto Acid Dehydrogenase E1, Beta Polypeptide) $93.06 $104.77
81465 Test For Detecting Genes Associated With Disease, Whole Mitochondrial Genome $915.73 $1,018.44
86215 Measurement Of Dna Antibody $12.93 $123.58
81540 Gene Analysis (cancer) $3,671.76 $7,697.88
88285 Chromosome Analysis For Genetic Defects, Additional Cells Counted, Each Study $26.35 $86.79
81460 Test For Detecting Genes Associated With Disease, Genomic Sequence, Must Include Sequence Analysis Of Entire Mitochondrial Genome $1,250.20 $1,727.01
0172U Dna Gene Analysis (brca1, Dna Repair Associated And Brca2, Dna Repair Associated) For Detection Of Mutations Associated With Breast Cancer $2,958.79 $4,040.00
81170 Gene Analysis (abl Proto-Oncogene 1, Non-Receptor Tyrosine Kinase) $293.11 $624.92
81257 Gene Analysis (alpha Globin 1 And Alpha Globin 2) For Common Deletions Or Variant $99.93 $613.00
81261 Gene Rearrangement Analysis (immunoglobulin Heavy Chain Locus) To Detect Abnormal Clonal Population Amplified Methodology $193.84 $526.57
81306 Gene Analysis (nudix Hydrolase 15) For Common Variants $285.13 $301.15
81236 Gene Analysis (enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit) Of Full Sequence $277.22 $334.59
81254 Gene Analysis (gap Junction Protein, Beta 6, 30kda, Connexin 30), Common Variants $34.30 $49.07
81216 Gene Analysis (breast Cancer 2) Of Full Sequence $181.42 $216.02
81175 Gene Analysis (additional Sex Combs Like 1, Transcriptional Regulator) Full Sequence Analysis $662.54 $722.96
88274 Chromosome Analysis For Genetic Defects, Analyze 25-99 Cells $41.48 $223.18
0352U Detection Of Bacteria Causing Vaginosis And Vaginitis By Multiplex Amplified Nucleic Acid Probe Technique $136.02 $316.91
81264 Gene Rearrangement Analysis (immunoglobulin Kappa Light Chain Locus) To Detect Abnormal Clonal Population $169.22 $404.60
0356U Onc Orop 17 Dna Ddpcr Alg $811.14 $2,200.00
81310 Gene Analysis (nucleophosmin) Exon 12 Variants $240.73 $538.13
0038U Measurement Of Vitamin D In Serum $29.01 $48.78
81287 Gene Analysis (o-6-Methylguanine-Dna Methyltransferase) For Promoter Methylation $122.15 $302.92
81430 Test For Detecting Genes Causing Hearing Loss Genomic Sequence Analysis Panel, At Least 60 Genes $1,592.50 $2,203.59
0024U Measurement Of Glycosylated Acute Phase Proteins $30.24 $68.33
88261 Chromosome Analysis For Genetic Defects, Count 5 Cells $258.33 $725.52
0027U Gene Analysis (janus Kinase 2) Of Targeted Sequence Exons 12-15 $118.55 $497.29
81352 Gene Analysis (tumor Protein 53) Targeted Sequence Analysis $321.14 $853.08
81449 Targeted Genomic Sequence Analysis Panel Of Rna Of 5-50 Genes Associated With Solid Organ Neoplasm $585.95 $1,777.40
81435 Test For Detecting Genes Associated With Colon Cancer, Genomic Sequence Analysis Panel, At Least 10 Genes $590.00 $3,831.76
0288U Pcr Measurement Of 11 Genes (bag1, Brca1, Cdc6, Cdk2ap1, Erbb3, Fut3, Il11, Lck, Rnd3, Sh3bgr, Wnt3a) And 3 Reference Genes (esd, Tbp, Yap1), In Tumor Tissue, With Algorithmic Interpretation Reported As A Recurrence Risk Score $3,789.14 $6,500.00
0026U Dna And Microrna Gene Analysis Of Thyroid Nodule Tissue $3,496.58 $4,046.96
0109U Dna Test For Detection Of 4 Aspergillus Species $139.78 $357.00
81245 Gene Analysis (fms-Related Tyrosine Kinase 3) Internal Tandem Duplication Variants $161.21 $383.19
81276 Gene Analysis (kirsten Rat Sarcoma Viral Oncogene Homolog), Additional Variants $189.11 $373.45
0090U Mrna Gene Expression Profiling Of 23 Genes In Skin Melanoma Tissue Sample $1,719.90 $4,250.00
0308U Analysis Of 3 Proteins (high Sensitivity [hs] Troponin, Adiponectin, And Kidney Injury Molecule-1 [kim-1]) In Plasma Specimen, Algorithm Reported As Risk Score For Obstructive Coronary Artery Disease $382.93 $586.00
0129U Gene Analysis Of Genes Associated With Hereditary Breast Cancer And Related Disorders For Gene Sequence And Duplication Or Deletion Variants $1,273.71 $6,789.38
0309U Analysis Of 4 Proteins (nt-Probnp, Osteopontin, Tissue Inhibitor Of Metalloproteinase-1 [timp-1], And Kidney Injury Molecule-1 [kim-1]) In Plasma Specimen, Algorithm Reported As Risk Score For Major Adverse Heart Event $382.93 $586.00
81436 Test For Detecting Genes Associated With Colon Cancer, Duplication/deletion Analysis Panel, At Least 5 Genes $573.20 $1,361.79
81552 Mrna Gene Expression Analysis Of 15 Genes In Eye Melanoma O Tissue Or Fine Needle Aspirate $7,602.22 $8,640.00
0119U Measurement Of Ceramides For Assessment Of Heart Disease Risk $82.08 $116.83
0061U Spatial Frequency Domain Imaging Of Skin $24.60 $50.22
81324 Gene Analysis (peripheral Myelin Protein 22), Duplication Or Deletion Analysis $733.40 $783.21
0105U Measurement Of Tumor Necrosis Factor Receptor 1a, Receptor Superfamily 2 (tnfr1, Tnfr2), And Kidney Injury Molecule-1 (kim-1) In Plasma To Evaluate Risk Of Rapid Kidney Function Decline $926.38 $1,200.00
81284 Gene Analysis (frataxin) For Abnormal Alleles $134.12 $167.87
81188 Gene Analysis (cystatin B) For Abnormal Alleles $134.26 $152.26
0363U Onc Urthl Mrna 5 Gen Alg $742.27 $2,995.00
0329U Exome And Transcriptome Sequence Analysis Of Dna And Rna From Tumor With Dna From Normal Blood Or Saliva For Subtraction, Report Of Clinically Significant Mutations With Therapy Associations $2,853.69 $7,200.00
0375U Onc Ovrn Bchm Asy 7 Prtn Alg $877.69 $1,495.00
0353U Detection Of Chlamydia Trachomatis And Neisseria Gonorrhoeae By Multiplex Amplified Dna Probe Technique $68.23 $222.29
81220 Gene Analysis (cystic Fibrosis Transmembrane Conductance Regular) Common Variants $537.05 $948.28
0250U Gene Analysis Of 505 Genes Associated With Solid Organ Cancer In Tumor Tissue Sample, Targeted Genomic Sequence Interrogation For Somatic Alterations, Microsatellite Instability And Tumor-Mutation Burden $2,844.41 $4,983.72
86723 Analysis For Antibody To Listeria Monocytogenes (bacteria) $12.93 $33.73
81520 Gene Analysis Of Breast Tumor Tissue, Profiling By Hybrid Capture Of 58 Genes $2,432.60 $7,233.89
82016 Chemical Analysis For Genetic Disorder $15.77 $45.08
81252 Gene Analysis (gap Junction Protein, Beta 2, 26kda, Connexin 26), Full Gene Sequence $99.10 $127.04
82017 Chemical Test For Genetic Disorder $16.47 $212.37
81434 Gene Analysis (retinal Disorders), Genomic Sequence $585.95 $1,946.16
0361U Neurflmnt Lt Chn Dig Ia Quan $16.89 $903.92
88283 Chromosome Analysis For Genetic Defects, Additional Specialized Banding Technique $67.23 $229.00
81120 Gene Analysis (isocitrate Dehydrogenase 1 [nadp+], Soluble) For Common Variants $188.62 $409.39
0045U Mrna Gene Analysis Of 12 Genes In Breast Ductal Carcinoma In Situ Tumor Tissue $3,795.54 $4,620.00
0058U Measurement Of Antibodies To Merkel Cell Polyoma Virus Oncoprotein In Serum $316.50 $372.29
0064U Antibody Testing For Syphilis $30.56 $88.85
0391U Onc Sld Tum Dna&rna 437 Gen $3,430.00 $6,500.00
81420 Test For Detecting Genes Associated With Fetal Disease, Aneuploidy Genomic Sequence Analysis Panel $740.86 $1,964.98
81121 Gene Analysis (isocitrate Dehydrogenase 2 [nadp+], Mitochondrial) For Common Variants $287.20 $581.67
0101U Gene Sequence Analysis Panel Of 15 Genes Associated With Hereditary Colon Cancer And Related Disorders $1,709.07 $6,800.00
81412 Test For Detecting Genes For Disorders Related To Ashkenazi Jews, Genomic Sequence Analysis Panel, At Least 9 Genes $2,399.59 $2,470.18
81441 Gene Sequence Analysis Panel At Least 30 Genes Associated With Inherited Bone Marrow Failure Syndromes $2,399.59 $2,761.92
81231 Gene Analysis (cytochrome P450 Family 3 Subfamily A Member 5) For Common Variant $171.31 $216.26
81232 Gene Analysis (dihydropyrimidine Dehydrogenase) For Common Variant $168.50 $377.72
81347 Gene Analysis (splicing Factor [3b] Subunit B1) For Detection Of Common Variants $186.54 $515.61
0411U Psyc Genom Alys Pnl 15 Gen $898.74 $4,700.00
81525 Gene Analysis (colon Related Cancer) $3,021.78 $4,420.00
0388U Onc Nonsm Cll Lng Ca 37 Gen $3,430.00 $7,800.00
0065U Non-Antibody Testing For Syphilis $14.43 $23.14
83950 Her-2 Oncoprotein (cancer Related Gene) Measurement $63.12 $389.57
81184 Gene Analysis (calcium Voltage-Gated Channel Subunit Alpha1 A) For Abnormal Alleles $134.17 $255.09
88355 Microscopic Genetic Analysis Of Muscle $74.20 $449.80
0235U Gene Analysis (phosphatase And Tensin Homolog), Full Gene Analysis $588.00 $900.00
81234 Gene Analysis (dm1 Protein Kinase) For Abnormal Alleles $133.18 $655.53
81187 Gene Analysis (cch-Type Zinc Finger Nucleic Acid Binding Protein) For Abnormal Alleles $132.14 $661.34
81522 Mrna Gene Expression Analysis Of 12 Genes In Breast Tumor Tissue $3,795.54 $3,900.00
0001U Red Blood Cell Typing $612.41 $1,156.05
81173 Gene Analysis (androgen Receptor) Of Full Sequence $295.32 $319.38
81304 Gene Analysis (methyl Cpg Binding Protein 2) Duplication Or Deletion Variants $147.00 $191.43
81168 Gene Analysis (ccnd1/igh (t(11;14))) Translocation Analysis $203.16 $426.07
81212 Gene Analysis (breast Cancer 1 And 2) For 185delag, 5385insc, 6174delt Variants $431.20 $1,084.80
81163 Gene Analysis (breast Cancer 1 And 2) Of Full Sequence $457.52 $1,059.32
81176 Gene Analysis (additional Sex Combs Like 1, Transcriptional Regulator) Targeted Sequence Analysis $232.10 $681.67
0164U Test For Detection Of Antibodies Associated With Irritable Bowel Syndrome In Plasma Specimen, Reported As Elevated Or Not Elevated $109.78 $222.38
0338U Evaluation Of Circulating Solid Tumor Cells In Peripheral Blood $245.76 $2,723.98
81278 Gene Analysis (igh@/bcl2 (t(14;18)) Translocation Analysis $192.59 $332.75
0166U Liver Disease Test Panel In Serum Specimen $490.73 $631.27
81350 Gene Analysis (udp Glucuronosyltransferase 1 Family, Polypeptide A1) For Detection Of Common Variants $220.48 $450.57
0059U Test For Presence Of Antibodies To Merkel Cell Polyoma Virus Oncoprotein In Serum $316.50 $339.29
0206U Cell Aggregation Testing Of Cultured Skin Cells For Alzheimer Disease, Reported As Positive Or Negative For Alzheimer Disease $2,171.09 $3,323.10
0337U Evaluation Of Plasma Cells For Detection Of Abnormalities Associated With Plasma Cell Disorders And Myeloma $245.76 $3,995.00
81355 Gene Analysis (vitamin K Epoxide Reductase Complex Subunit 1) Common Variants $86.44 $123.53
0023U Dna Gene Analysis For Acute Myelogenous Leukemia $238.15 $602.05
0343U Exosome-Based Analysis Of 442 Small Noncoding Rnas In Urine To Evaluate Risk Of Prostate Cancer $744.80 $1,200.00
81230 Gene Analysis (cytochrome P450 Family 3 Subfamily A Member 4) For Common Variant $171.31 $255.70
81293 Gene Analysis (mutl Homolog 1, Colon Cancer, Nonpolyposis Type 2) Known Familial Variants $324.38 $1,330.16
81507 Dna Analysis Using Maternal Plasma $779.10 $1,398.53
0152U Cell-Free Dna Sequencing Of Disease-Causing Organisms In Plasma Specimen, With Report For Significant Organisms $2,040.77 $2,235.63
0207U Immunofluorescence Testing Of Cultured Skin Cells For Alzheimer Disease, Reported As Probability Index For Alzheimer Disease $500.98 $766.80
0035U Testing For Presence Of Prion Protein In Cerebrospinal Fluid $415.00 $554.29
0051U Testing For Presence Of 31 Prescription Drugs In Urine Or Blood Specimen $189.84 $699.89
0034U Gene Analysis (thiopurine S-Methyltransferase) For Common Variants $455.17 $676.39
0349U Dna Analysis Of 27 Genes Involved In Drug Metabolism Or Processing, Report Including Gene-Drug Interactions $437.18 $505.44
81224 Gene Analysis (cystic Fibrosis Transmembrane Conductance Regular) Intron 8 Poly-T $165.37 $218.43
81204 Gene Analysis (androgen Receptor) For Characterization Of Alleles $134.26 $295.25
81470 Test For Detecting Genes Associated With Intellectual Disability, Genomic Sequence Analysis Panel, At Least 60 Genes $891.31 $3,027.96
0333U Survelliance For Liver Cancer In High Risk Patients Using Algorithm $1,280.21 $1,852.17
81244 Gene Analysis (fragile X Mental Retardation 1) For Characterization Of Alleles $43.99 $88.34
81269 Gene Analysis (alpha Globin 1 And Alpha Globin 2) For Duplication/deletion Variants $198.35 $719.71
81303 Gene Analysis (methyl Cpg Binding Protein 2) Known Familial Variant $117.60 $120.00
0174U Mass Spectrometry Testing For 30 Protein Targets In Tissue Specimen To Predict Benefit Of Cancer Therapy Agents $1,279.26 $6,400.00
81172 Gene Analysis (fragile X Mental Retardation 2) For Characterization Of Alleles $269.33 $481.71
0106U Evaluation Of Gastric Emptying By Measurement Of Radiolabeled Carbon Dioxide In Breath Specimens $857.00 $1,472.88
81248 Gene Analysis (glucose-6-Phosphate Dehydrogenase) For Known Familial Variant $367.74 $563.00
88263 Chromosome Analysis For Genetic Defects, Count 45 Cells For Mosaicism $144.33 $529.87
0084U Dna Red Blood Cell Antigen Typing $705.60 $1,080.00
0249U Analysis Of 32 Phosphoproteins And Protein Analytes Associated With Breast Cancer, With Interpretation And Report $2,174.75 $3,900.00
81277 Cancer Cytogenomic Array Gene Analysis $1,136.80 $3,196.45
0202U Test For Detection Of Respiratory Disease-Causing Organisms From Back Of Nose And Throat (nasopharynx) Specimen, 22 Target Organisms Including Severe Acute Respiratory Syndrome Coronavirus 2 $326.72 $614.48
81425 Test For Detecting Genes Associated With Disease, Genome Sequence Analysis $4,927.40 $11,994.23
88289 Chromosome Analysis For Genetic Defects, Additional High Resolution Study $33.74 $154.47
0380U Rx Metb Advrs Trgt Sq Aly 20 $898.74 $2,500.00
81215 Gene Analysis (breast Cancer 1) For Known Familial Variant $367.74 $578.82

Reading Genetic/Molecular Test Pricing Data

The 298 procedure codes grouped under Genetic/Molecular Test share a common clinical taxonomy in the CMS Medicare Physician & Other Practitioners dataset. Across this category, the average Medicare payment is $795.12 - the figure Medicare actually reimburses providers for the allowed amount after geographic and specialty adjustments. DNA, RNA, and genetic testing including proprietary lab tests Each CPT/HCPCS code in the table above carries its own fee schedule value determined by CMS's Resource-Based Relative Value Scale (RBRVS), which weights physician work, practice expense, and professional liability.

Billed charges, the "Billed" column, often run several multiples above Medicare allowed amounts. This is expected under US chargemaster pricing practices: providers list a gross rate, then accept negotiated write-offs from Medicare, Medicaid, and commercial insurers under participation agreements. A high markup ratio does not necessarily indicate overcharging, because almost no payer pays the full billed charge. However, uninsured and out-of-network patients can be exposed to amounts closer to the billed rate, which is why federal rules now require providers to publish cash and negotiated prices through the Hospital Price Transparency initiative.

Volume matters when interpreting category-level data. Procedures with millions of annual services, evaluation visits, common diagnostic work, reflect stable, well-benchmarked pricing. Lower-volume codes may show wider variation across providers and settings because small sample sizes produce less stable averages. When comparing specific procedures, drill into the individual procedure page for state-level breakdowns, provider counts, and commercial pricing estimates derived from RAND 2024 research. This page presents CMS reference data for educational use; it does not constitute medical, legal, or financial advice.

Data sourced from the CMS Medicare Physician and Other Practitioners dataset. See our methodology for details. Retrieved and formatted by PlainProcedure  · Verify with CMS →

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from CMS (Centers for Medicare and Medicaid Services). Consult a qualified professional before making decisions based on this data.

Related Guides

Every figure on PlainProcedure is rendered directly from CMS Medicare Physician & Other Practitioners data, no number is typed in by an editor. This page draws directly on CMS Medicare Physician & Other Practitioners data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.